Description

Super-Resolution Microscopes: Unveiling the Sub-Diffraction Limit

Traditional light microscopy is limited by the diffraction limit of light, hindering the visualization of nanoscale structures. Super-resolution microscopy techniques overcome this limitation, enabling the observation of cellular components and processes at resolutions far beyond what was previously possible. These groundbreaking instruments provide unparalleled insights into the intricate workings of biological systems, materials science, and more.

Unleash the Power of Sub-Diffraction Imaging:

Our range of super-resolution microscopes offers cutting-edge technology for high-resolution imaging. We provide solutions tailored to diverse research needs, from single-molecule localization microscopy (SMLM) to structured illumination microscopy (SIM).

Key Features & Benefits:

• Unprecedented Resolution: Achieve resolutions significantly beyond the diffraction limit, revealing intricate details of cellular structures and processes previously invisible. Depending on the specific technique and sample, resolutions down to tens of nanometers are achievable.
• Advanced Imaging Modalities: Choose from a variety of techniques, including:
  • PALM/STORM (Photoactivated Localization Microscopy/Stochastic Optical Reconstruction Microscopy): Localize individual fluorescent molecules to achieve exceptional resolution and precise 3D reconstructions.
  • dSTORM (Direct Stochastic Optical Reconstruction Microscopy): A variation of PALM/STORM, often featuring improved ease of use and data processing.
  • SIM (Structured Illumination Microscopy): Uses structured illumination patterns to enhance resolution by a factor of two compared to conventional microscopy. This technique is particularly suitable for live-cell imaging.
  • Other Advanced Techniques (Available upon request): Our offerings are constantly evolving, and we can provide customized solutions incorporating the latest super-resolution methodologies, such as MINFLUX and other advanced techniques.
• High-Sensitivity Detection: Our systems feature highly sensitive detectors, maximizing the signal-to-noise ratio and enabling the visualization of faint fluorescent signals.
• Versatile Applications: Suitable for a wide range of applications, including:
  • Cellular Biology: Study the organization and dynamics of cellular structures, such as organelles, proteins, and membranes.
  • Neuroscience: Visualize intricate neuronal networks and synaptic connections.
  • Materials Science: Analyze nanoscale materials and their properties.
  • Biomedical Research: Investigate disease mechanisms and develop novel therapies.
• Intuitive Software: Powerful, user-friendly software packages for image acquisition, processing, and analysis simplify workflow and accelerate research progress. Advanced features include automated image stitching, 3D reconstruction, and colocalization analysis.
• Customizable Configurations: We offer highly customizable systems to meet specific research requirements. Options include different laser sources, detectors, objectives, and environmental control chambers.
• Comprehensive Support: Benefit from our expert technical support and training, ensuring optimal performance and maximizing the lifespan of your microscope.

Specifications (Vary by Model):

• Magnification: Variable, depending on objectives (high numerical aperture objectives are crucial for super-resolution).
• Resolution: < 20 nm (dependent on technique and sample)
• Excitation Sources: Multiple laser lines available (e.g., 405 nm, 488 nm, 561 nm, 647 nm).
• Emission Detection: High-sensitivity detectors (e.g., EMCCD, sCMOS).
• Software: Advanced image acquisition, processing, and analysis software.

Contact us today to discuss your research needs and explore the possibilities of super-resolution microscopy. We'll help you select the ideal system to unlock new discoveries in your field.